Mikulov is a lovely little town, population 7800, on the Czech-Austrian border. It makes a great day trip from Brno or as part of a cycling or walking tour through South Moravia. While you can take a bus from Brno to Mikulov, it is much nicer to take the train to Popice and then walk over the Palava Hills to Mikulov.
Practical Information You can check out the bus and train timetables on the Czech transport website. Click on the Union Jack in the bottom right hand corner if you need it in English.